Ukusetshenziswa Kwezokwelapha
Ezinye izifundo zacabanga ukuthi i-AS ingabopha ngqo kuma-G-protein-coupled-receptors angachazwanga noma kuma-nonreceptors tyrosine kinase c-SRC, yiziphi izici zemithi ezihlala zingacaci. Ngaphezu kwalokho, ukuqashwa kwamakhasethi wokufaka isibambiso ngokusebenza kwe-AR, eceleni kwendlela ye-classical genomic, kufanele futhi kucatshangelwe . Okokuqala, Izinhlanganisela ezisebenzayo zebhayoloji zingabopha kuma-receptors wezinhloso, ukukhuthaza imiphumela yabo yomzimba. Okwesibili, I-AS ingathwala ukunciphisa kwe-5α, nge-enzyme 5α-reductase, okuholela kuma-metabolites athile .
Ikhishwa ngomjikelezo wokushintshwa kosuku futhi ukwethulwa kwayo kuphakanyisiwe kuphendula ukucindezela kanye nokugxila kwe-glucose egazini ephansi. Isebenza ukukhulisa ushukela wegazi nge-gluconeogenesis, ukucindezela amasosha omzimba, nokusiza ekwenziweni kwamafutha emzimbeni, amaprotheni, nama-carbohydrate.
Ngubani owagijimela u-Arnold Schwarzenegger?
Owayengumphathi waseCalifornia u-Arnold Schwarzenegger nonkosikazi wakhe uMaria Shriver bathe bayahlukana ngemuva 25 iminyaka yomshado. “Ngemuva kokucabanga okukhulu, ukukhombisa, ingxoxo nomthandazo, sifike kulesi sinqumo,” kusho laba esitatimendeni.
Isitaki seHormone Stack
Ipea protein inokuqukethwe okuphezulu kwefayibha futhi ayinazo izakhi zokungezwani komzimba futhi ngenxa yalokhu kulula ukugaya njengoba kuqhathaniswa ne-whey protein. Ipea protein iphrotheni egaya kancane kancane futhi ilungele ukukubamba ugcwele isikhathi eside. Ngo-October 1994, iDietary Supplement Health and Education Act yasayinwa yaba ngumthetho ngaphakathi e-USA. Ngaphansi kwe-DSHEA, umthwalo wokunquma ukuphepha kwamaphilisi wokudla okushintshwe kusuka kuziphathimandla kuya kumenzi futhi izithako azisadingi imvume evela e-U.S.. Kusukela ngaleso sikhathi abakhiqizi kwakungafanele banikeze i-FDA nobufakazi bokuqinisekisa ukuphepha noma ukusebenza ngaphandle kokuthi kufakwe isithako esisha sokudla.
Nawa ama-PED akhethwayo, okuyinto empeleni esingakukhuthazi ukuyithatha. Uma ungaba nezinsolo mayelana nokusebenzisa izidakamizwa emdlalweni obamba iqhaza kuwo, vakashela reportdoping.com. Khuluma nomsebenzi wakho wokunakekelwa kahle uma uhlangabezana nezimpawu okungenzeka zihlobene nalokhu kuthengiswa, ikakhulukazi isicanucanu, ubuthakathaka noma ukukhathala, imfiva, ubuhlungu besisu, ubuhlungu besifuba, ukuphelelwa umoya, i-jaundice , noma umchamo onsundu noma onsundu. Abanye abasebenzisa izimpahla zokwakha umzimba basebenzisana “ekuqongeleleni,”Usebenzisa ukuthengisa okuningi ukuthuthukisa imiphumela noma" izici. " Lezi zingxube zingabeka amakhasimende engcupheni enkulu yokuphendula okubucayi nokusongela impilo.
- Lokhu kukhombisa ukuthi abantu bayakwazi ukujwayela okwengeziwe kaningi futhi isikhathi eside, ngokubuyiselwa okuthuthukisiwe.
- Ukugcinwa kwamanzi kungabuye kube njalo, futhi kungaholela ekutheni imisipha ifune ukuthamba noma ukuqunjelwa.
- Izingozi ezibalulekile zokuphila kahle zihlobene nokuhlukunyezwa kwama-anabolic steroids.
Ukugwema ukudlula ngaphezulu, ukuqeqeshwa okuvamile njalo kufanele kuhlangatshezwane okungenani nenani elilinganayo lokubuyiselwa okunenjongo. Ukuhlinzekwa ngesikhathi esifanele kwama-carbohydrate, amaprotheni, nama-micronutrients ahlukahlukene afana namavithamini, amaminerali, amakhemikhali amakhemikhali, ngisho nezithako zokudla zibaluleke kakhulu. Ukungasebenzi kahle kwengqondo, ngokwethukela okubizwa nge- “bigorexia” , angabika ngokweqile kwabanye abantu yini ongayithatha ukuze uklebhuke. Abagulayo baba nomuzwa wokuthi abakhule ngokwanele noma abanemisipha ngokwanele, okubaphoqa ukuthi badlule ngokweqile ukuze bazame ukufinyelela umgomo womzimba wabo. Intuthuko yakamuva yokwakha umzimba ukufaka i-synthol ezicutshini zemisipha ukudala ama-bulges amakhulu, noma ukufaka i-PMMA emisipheni ukuyakha.
Ingabe i-steroids ivunyelwe ekwakheni umzimba?
Ukulwa nokusetshenziswa kwe-anabolic steroid futhi unethemba lokuba yilungu le-IOC, i-IFBB yethule ukuhlolwa kwe-doping kokubili i-steroids nezinye izinto ezivinjelwe. Yize ukuhlolwa kwe-doping kwenzeka, iningi labakhi bomzimba abaqeqeshiwe lisasebenzisa ama-anabolic steroids ukuncintisana.
Abanye odokotela bazama ukuvuma ukuthi ama-steroids awawona umlutha, kodwa uConigliaro ucabanga kunoma yiliphi elinye icala. Intsha izwa ngempela uma ithatha ama-steroids, bazothuthukisa ikhono labo kwezemidlalo futhi ngethemba lokuthi bazobangenisa emidlalweni yasekolishi.
Ku-CNS, Ukuphathwa okuphikelelayo kwe-nandrolone decanoate kumagundane kubonisiwe ukwehlisa umsebenzi we-glutathione peroxidase ku-hippocampus naku-pre-frontal cortex. . I-Gpx ivusa uketshezi kwamakhemikhali amabili e-monomeric glutathione yi-hydrogen peroxide ku-H2O kanye ne-glutathione disulfide, ngaleyo ndlela kwehlise ukuhlushwa kwe-hydrogen peroxide. Kanjalo, ukwehliswa phansi kokulawulwa komsebenzi we-Gpx yi-AS kuzokwandisa ukutholakala kwe-hydrogen peroxide, ehambisana ne-lipoperoxidation ephakeme futhi yehlise izinsalela ze-thiol ezibangelwa ukusakazwa kwe-AS ngaphakathi kobuchopho . Ucwaningo lokuhlola lukhombisile ukuthi ukuvezwa kokugxila okuphezulu kwe-AS kungakhipha i-apoptosis ngayinye yangaphandle neyangaphakathi. Ukuphathwa kwesikhathi eside kwe-nandrolone decanoate kugcina ekusebenzeni okuphakeme kwe-caspase-three ne-apoptosis kuzo zonke izakhiwo ze-hippocampal kanye ne-cortical .
Yiziphi izigaba ze-steroids?
Kulezo zigaba ezimbili kunezinhlobo ezinhlanu ngokuya ngama-receptors abopha kuwo: i-glucocorticoids kanye ne-mineralocorticoids (womabili ama-corticosteroids) kanye ne-androgens, ama-estrogens, nama-progestogens (i-steroids yocansi).
Le podcast akuyona ukuzama nokusebenzisa imithi noma ukunikeza izincomo ezithile zezokwelapha. Lokhu kusikisela ukuthi ama-steroids angenza izingqinamba eziyingozi ngendlela ye-cardiomyopathy, kodwa-ke lokho kufanele kuyeke, ukuthi iningi layo lizolulama. Nokho, kungenzeka kube khona imininingwane engenampilo ehambisana nalezi zindaba ezinhle kakhulu, ikakhulukazi kungaba nomunye umphumela futhi lokho ukuqina kwemithambo. Ukuphuza ama-steroid kuphazamisa ukusimama kwezingxenyana ze-cholesterol yakho futhi kuphumele ekusheshisweni, kusheshiswe kakhulu, ukuqina komthambo, okuthiwa yi-atherosclerosis.
Ingxenye 2 umuthi udinga ilayisense ye-Home Office yokungenisa nokuthekelisa ngaphandle kwalapho into ingohlobo lomkhiqizo wokwelapha futhi ingeyokuzibusa komuntu. UMongameli John F. UKennedy wayephathwa ama-steroids ngamunye ngaphambili futhi nangobumongameli bakhe. Eminyakeni eyishumi nesishiyagalolunye, bekuvele sekubonwa ukuthi ama-testes afaka i-androgen ethe xaxa kune-androstenone, namaqembu amathathu ososayensi, uxhaswe yizinkampani ezincintisanayo ezenza imithi ngaphakathi eNetherlands, Germany, naseSwitzerland, wagijimela ukuyihlukanisa. Ukuhlanganiswa kwamakhemikhali kwe-testosterone kwenziwa ngo-Agasti ngalowo nyaka, lapho uButenandt noG.
