Puas chloroquine muaj quinine

Zoo tib yam thiab fraternal menyuam ntxaib tau kuj tau qhia kom muaj itched, li cas los xij, qhov no yog ntau npaum li cas zoo li youngsters ntawm qhov zoo tib yam txiv thiab niam uas ua tsis yog txhua txhua khaus nram qab no chloroquine thawj coj. Muaj li cas los xij ib qho uas txawv tsis pub dhau cov kev siv ntawm khaus tom qab siv chloroquine nyob rau hauv malaria tshuaj. Enzyme deficiency coj mus rau glucose-6-phosphate dehydrogenase tau pom yuav tsum tau kuj muaj ntau heev cov itchers tshaj uas tsis yog-itchers.

Rau cov ntshav schizoniticides, heme yog ib tug heev lub hom phiaj, raws li yog folic acid synthesis, thiab mitochondrial electron thauj. Tshuaj kev sib tshuam tej zaum yuav hloov yuav ua li cas koj cov tshuaj ua hauj lwm los yog txhim khu koj muaj kev phiv loj heev. Khaws ib daim qhia txog cov tag nrho cov khoom muag koj siv (xws li tshuaj / nonprescription tshuaj thiab herbal khoom) thiab qhia nws ua ke nrog koj tus kws kho mob thiab tus kws muab tshuaj. Tsis txhob pib, tsum, los yog hloov cov tshuaj ntawm tshuaj nrog tawm koj tus kws kho mob pom zoo. Chloroquine phosphate yog nyob rau hauv ib chav kawm ntawv ntawm cov tshuaj hu ua antimalarials thiab amebicides.

Muaj roughly 300 kev tshwm sim ntawm kev mob loj malaria nyob rau hauv lub tebchaws United States txhua xyoo, feem ntau ntawm lawv kis tau los ntawm mus ncig teb chaws rau malaria-teb thoob ntiaj teb qhov chaw. Loj malaria yuav tsum muaj leej twg nrog tso dej (IV) antimalarial tshuaj.

Cov neeg feem ntau qhia dua qhov tob ntawm khaus thaum twg lawv siv lub sulphate npaj. Ib txhia neeg feem ntau qhia khaus rau lub ntsiav tshuaj nrog tawm khaus rau lub injectable formulation. Qhov no txhais tau tias chloroquine hais tias cov kev siv ntawm chloroquine khaus kuj muab nws txo qis los ntawm kev Process lub txoj kev thiab daim ntawv ntawm kev tswj hwm raws li ua ntej lawm qhia.

Lub US tau tau 4 lab cinchona noob los ntawm lub Philippines thiab pib khiav hauj lwm cinchona plantations nyob rau hauv Costa Rica. Tsis tas li ntawd, lawv pib ntxawm qus cinchona tawv los ntawm lub Cinchona Missions. Kaum ntawm pua ​​pua ntawm US pab tub rog nyob rau hauv teb chaws Africa thiab South Pacific tuag vim cov tsis muaj quinine.

• Common phiv puag nqaij cov teeb meem, tsis muaj qab los noj mov, raws plab, thiab daim tawv nqaij sawv pob.
• Lwm yam qhov ncauj xaiv muaj xws li atovaquone-proguanil (Malarone ®), quinine, los yog mefloquine.
• Rau txoj kev kho ntawm cutaneous lupus erythematosus, lub qub qub koob tshuaj ntau yog 200-plaub puas mg hnub kom txog rau thaum ib tug kho lus teb yog tiav.
• Chloroquine yuav tsum tsis txhob yuav siv nyob rau hauv cov yam kom txog thaum lub profit rau tus neeg mob ntau tshaj lub peev xwm txoj kev txhawj xeeb.

Yuav ua li cas yog chloroquine phosphate ntsiav tshuaj rau

Tus yuam sij hloov zoo li yuav K76T vim tsis muaj chloroquine resistant cais yog cov qus hom lysine ntawm txoj hauj lwm 76. Nws yuav tsum mus yuav nto moo uas nquag heev heev lwm change yog nto moo nyob rau hauv chloroquine resistant malaria, Txawm li cas los thiaj tau tuaj lub K76T amino acid sib puav yog pom li qhia siv kuj nyob rau hauv lub chloroquine resistant malaria. Chloroquine yuav tsum siv tsis tau rau txoj kev kho ntawm P. falciparum kab mob los ntawm qhov chaw ntawm chloroquine kuj los malaria tshwm sim nyob rau hauv sufferers qhov twg chloroquine prophylaxis tau ua tsis tau tejyam. Dua li ntawm qhov ua dab neeg vim kuj cab mus chloroquine nyob rau hauv ib co Cheebtsam ntawm lub ntiaj teb no,, cov tshuaj no nyob qis qis ib tug ntawm lub thoob plaws rau malaria kev kho mob,. Nyob rau hauv qhov kev tshawb fawb rau cov thawj lub sij hawm, lub opposed los ntawm chloroquine thiab quinine li orchitis thiab uro-genitaly paug nyob rau hauv cov txiv neej nas tau soj ntsuam.

yog ib tug txheej txheem antimalarial neeg sawv cev uas feem ntau tau nyob rau hauv cov huab toxicity thaum noj nyob rau hauv overdose. Chloroquine yog structurally txuam rau quinine thiab quinidine, thiab cardiotoxicity ensuing los ntawm ib yam ntawm cov tshuaj mas siv tej zaum yuav indistinguishable. yog cov tshuaj ntawm lwm nyob rau hauv ob peb malaria-teb chaw dawb ntawm CRPf. Combining chloroquine thiab proguanil yog ib qho kev xaiv rau CRPf thaum lwm thawj-line antimalarials yog txhob.

Antirheumatic koob tshuaj chloroquine yog siab tshaj cov siv rau malaria kev tiv thaiv. Chloroquine kis mus rau hauv niam cov kua mis thiab yuav ua mob rau ib tug kev pub niam mis tus me nyuam. Tsis txhob pub niam mis thaum noj cov tshuaj no nrog tawm ua ntej tham rau koj tus kws kho mob. Cov zaub mov thiab Drug Administration (FDA) thawj tso cai chloroquine nyob rau hauv 1949. Cov compound muaj zog intrinsic antimalarial kev ua si thiab tej zaum yuav ua raws li ib tug sib tw inhibitor ntawm lub thwj toob ntawm chloroquine mus rau lub putative transporter.

Quinine twb pib siv raws li ib tug malaria kev kho mob los ntawm lub hnub ntawm colonial Is Nrias teb. Txawm li cas los ntawm raws nraim yuav ua li cas nws twb pom, cov thawj cov ntaub ntawv ntawm nws siv li malaria yog kaw nyob rau hauv 1630 Peru. Nws hais ntxiv rau siv rau nws antimalarial zog txog cov Kaum cuaj twenties, thaum lwm cov tshuaj muaj tsawg pliaj sab los coj nws qhov chaw, zoo li chloroquine. Thiab ib qhov twg ntawm txoj kev, quinine sab nws txoj kev mus rau hauv peb cocktails. Ib txhia kws kho mob tsis ntuas ib tug rigorously saib xyuas 4- 6-lub lim tiam mus sib hais ntawm quinine rau cov neeg mob uas nws txhais ceg tu-sauv yog tsis ntaug los ntawm lwm cov txhais tau tias.

Thaum tus neeg mob muaj peev xwm zam qhov ncauj tshuaj, hloov mus rau ib lub qhov ncauj rov qab rau kev kho mob. Placement ntawm nasogastric raj los yog siv cov antiemetics yuav tsum xav tias-txog los pab txhawb koom haum saib xyuas ntawm qhov ncauj tshuaj. IV artesunate tej zaum yuav prepositioned ntawm xaiv CDC yam tseem ceeb ntawm kev faib thoob plaws hauv lub tebchaws United States. Thaum IV artesunate yog tso tawm, thov tsev kho mob yuav tau info txog uas ib qho ntawm ntau ob khoom yog raug xa, qhov twg lub artesunate yog los ntawm, thiab lub sij hawm uas tuaj txog rau lo lus uas peb lub tshav dav hlau.